OpenEvidence Overview

OpenEvidence is a revolutionary medical information platform that leverages advanced artificial intelligence to organize and expand the world's collective medical knowledge. Launched from the Mayo Clinic Platform Accelerate program, its mission is to combat the overwhelming information overload faced by medical professionals today. With the volume of medical research doubling every few years, OpenEvidence provides a crucial tool to help physicians, researchers, and healthcare professionals stay current with the latest clinical evidence, ultimately improving patient outcomes.

The platform is trusted by medical professionals at over 10,000 care centers across the United States and is backed by leading investors such as Sequoia, Google Ventures, and the Mayo Clinic. It distinguishes itself by integrating multimedia and clinical findings directly from the most prestigious medical journals, including The New England Journal of Medicine (NEJM) and the JAMA Network.

How to use OpenEvidence

Using OpenEvidence is designed to be intuitive and seamlessly integrate into a clinician's workflow. Verified healthcare professionals can sign up for a free account and immediately begin querying the platform with natural language questions. The process is straightforward:

Ask a Clinical Question: Users can type specific questions related to patient care. The platform is optimized for queries such as constructing a diagnostic workup, asking about the latest treatment options for a specific condition, or inquiring about precise drug dosing and interactions.
Receive Synthesized Evidence: Instead of a list of links, OpenEvidence provides a synthesized, easy-to-read summary of the most relevant, up-to-date evidence. The AI analyzes and aggregates data from millions of research papers and clinical trials in seconds.
Explore Sources: Every piece of information is backed by citations from reputable sources. Users can utilize the "Why Was This Source Cited?" feature to understand the context and relevance of each source, ensuring full transparency and trust in the answers provided.
Stay Updated: Users can opt-in to receive notifications when new, relevant evidence emerges regarding a previous question, ensuring their knowledge remains current.

Core Features of OpenEvidence

AI-Powered Synthesis: Aggregates and synthesizes vast amounts of medical literature to provide concise, actionable answers.
Prestigious Content Integration: Features clinical findings and multimedia content from The New England Journal of Medicine (NEJM) and the JAMA Network.
Comprehensive Query Capabilities: Supports a wide range of clinical questions, including diagnostic workups, treatment options, and drug dosing.
HIPAA Compliance: Built with stringent security measures to protect data, fully complying with HIPAA Privacy, Security, and Breach Notification Rules. Data is encrypted in transit and at rest.
Continuing Medical Education (CME): Offers CME credits, allowing professionals to learn while staying compliant with their educational requirements.
High Accuracy: The underlying AI became the first in history to score above 90% on the United States Medical Licensing Examination (USMLE), demonstrating its deep medical knowledge.
Mobile Accessibility: Available as a website and on dedicated iOS and Android apps, providing access anytime, anywhere.

Use Cases for OpenEvidence

OpenEvidence is versatile and can be used in various clinical and research settings:

Point-of-Care Decisions: A primary care physician can quickly verify the latest guidelines for managing hypertension in a patient with comorbidities.
Complex Case Consultation: A specialist can explore cutting-edge or experimental treatment options for a rare disease by querying the latest research.
Medical Education and Research: A medical resident can use the platform to build a differential diagnosis for a complex case, while a researcher can rapidly synthesize existing literature for a new study.
Pharmacist Support: A pharmacist can check for complex drug-drug interactions or find evidence for off-label drug use.

Advantages of OpenEvidence

The primary advantage of OpenEvidence is its ability to deliver trusted, evidence-based medical information with unparalleled speed and efficiency. It saves clinicians valuable time that would otherwise be spent manually searching through databases and journals. By providing synthesized answers from top-tier sources, it enhances the quality of clinical decision-making and supports better patient care. Its backing by the Mayo Clinic and top investors, along with its strong security posture (HIPAA compliance), builds a foundation of trust. Furthermore, being free for verified U.S. HCPs makes this powerful tool accessible to all who need it.

Pricing and Plans

OpenEvidence is completely free and offers unlimited access for all verified U.S. health care professionals (HCPs). Users can sign up on the website to get started.

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Updated at 2026-06-15

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