Lavo

Lavo Life Sciences is revolutionizing pharmaceutical research and development with its advanced AI-accelerated crystal structure prediction technology. Designed specifically for chemists, crystallographers, and drug development teams, Lavo addresses the complex and critical challenge of polymorphism in small molecule drugs. The core of its offering is the Crystal Console, a powerful web-based platform that provides a suite of computational tools to predict, analyze, and visualize crystal structures. By leveraging state-of-the-art AI, Lavo significantly saves time, reduces operational costs, and mitigates critical risks throughout the drug development lifecycle, enabling faster and more informed decision-making.

How to use Lavo

Users can leverage Lavo's capabilities through a streamlined workflow, either via its self-service platform or dedicated research services:
1. Access the Platform: Engage with Lavo through the intuitive, web-based Crystal Console or by commissioning their Contract Research services for expert-led projects.
2. Import Data: Easily upload existing crystal structure data using standard formats like CIF files. For experimental validation, upload Powder X-Ray Diffraction (PXRD) data, either as raw data files (XYE, CSV) or even as images, which the AI can digitize automatically.
3. Run Predictions: Initiate a virtual polymorph screening. The platform's AI, combined with advanced sampling techniques, efficiently explores the conformational space to identify potential crystal structures.
4. Analyze & Visualize: Utilize the interactive 3D viewer to inspect crystal packing and intermolecular interactions. Analyze the complete energy landscape using Lavo's proprietary neural network (Lavo-NN) and various quantum mechanical methods to pinpoint the most stable polymorphs.
5. Compare & Validate: Match experimental PXRD patterns against the library of predicted structures to confirm the presence of specific polymorphs in a sample, bridging the gap between computation and experiment.
6. Export & Integrate: Seamlessly export all results, including structures and analysis reports, in multiple formats (CIF, CSV) for internal documentation, publications, or integration with other third-party analysis tools.

Core Features of Lavo

• AI-Powered Crystal Structure Prediction: Employs physically-constrained AI models to deliver unprecedented accuracy in predicting the crystal structures of small molecule drugs.
• Virtual Polymorph Screening: Conducts high-throughput virtual screening to identify a comprehensive landscape of potential polymorphs and assesses their relative stability, mitigating the risk of late-appearing, problematic forms.
• Crystal Console Platform: An intuitive, web-based interface that centralizes structure import, interactive 3D visualization, and in-depth analysis in one place.
• Advanced Energy Calculation: Utilizes a proprietary neural network potential (Lavo-NN) and a variety of quantum mechanical methods for precise and reliable potential energy landscape analysis.
• PXRD Analysis and Digitization: A unique AI-powered tool that can extract and digitize Powder X-Ray Diffraction data directly from images (PNG, JPG, PDF) and files, and then compare it with predicted structures.
• Contract Research Services: Offers dedicated support and customized studies conducted by Lavo's team of expert scientists for companies that require specialized analysis or wish to outsource the computational workload.

Use Cases for Lavo

Lavo's technology is applicable across the pharmaceutical development pipeline:
• Early-Stage Drug Development: Pharmaceutical companies can screen drug candidates at the earliest stages to understand their solid-state properties, enabling more informed decisions on which candidates to advance.
• Formulation Optimization: Scientists can identify the most stable and manufacturable polymorph to optimize drug formulation, which directly impacts product stability, shelf-life, and bioavailability.
• Intellectual Property Strategy: The platform helps discover novel, patentable polymorphs that may possess improved properties, thereby strengthening the intellectual property portfolio of a new drug.
• Troubleshooting & Risk Mitigation: Research teams can use Lavo to investigate and resolve issues such as the appearance of unexpected crystal forms during manufacturing scale-up, preventing costly delays and potential batch failures.

Advantages of Lavo

Lavo provides a distinct competitive edge:
• Speed and Efficiency: Drastically reduces the timeline for crystal form identification from months of experimental work to just hours or days of computation.
• Comprehensive Risk Mitigation: Proactively identifies potential late-stage polymorphs that could otherwise derail development timelines and lead to regulatory hurdles.
• Significant Cost Reduction: Saves substantial R&D resources by minimizing the need for extensive, trial-and-error experimental screening.
• Deeper Scientific Insights: Uncovers novel and potentially more desirable polymorphs that traditional experimental methods might easily miss.
• Data-Driven Decision-Making: Provides comprehensive, reliable data to support critical decisions throughout the drug development process, from candidate selection to final formulation.

Pricing and Plans

Lavo does not list public pricing tiers on its website. The company operates on a custom pricing model tailored to the specific needs of pharmaceutical companies, biotech firms, and research institutions. Pricing is determined based on the scope of work, whether it involves access to the Crystal Console platform, the volume of computations, or dedicated contract research services. Interested parties are encouraged to book a demo or contact the Lavo sales team directly to discuss their project and receive a personalized quote.